[PDF][PDF] Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
Journal of clinical oncology, 2007•researchgate.net
Purpose A number of microarray studies have reported distinct molecular profiles of breast
cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These
were associated with different clinical outcomes. However, although the basal and the
ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)–positive
subtypes has been inconsistent. Therefore, refinement of their molecular definition is
needed.
cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These
were associated with different clinical outcomes. However, although the basal and the
ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)–positive
subtypes has been inconsistent. Therefore, refinement of their molecular definition is
needed.
Purpose
A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER)–positive subtypes has been inconsistent. Therefore, refinement of their molecular definition is needed.
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