A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior

S Flaisher-Grinberg, H Einat - Journal of pharmacological and toxicological …, 2009 - Elsevier
INTRODUCTION: The lack of appropriate animal models for bipolar disorder (BPD) is a
major factor hindering the research of its pathophysiology and the development of new drug
treatments. In line with the notion that BPD might represent a heterogeneous group of
disorders, it was suggested that models for specific domains of BPD should be developed.
The present study tested the possible utilization of the forced swim test (FST) as a model for
the heightened vigor and goal-directed behavior domain of mania, using mice with low …