Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate: a randomized controlled trial
JP Harris, MH Weisman, JM Derebery, MA Espeland… - Jama, 2003 - jamanetwork.com
ContextA number of therapies have been proposed for the long-term management of
corticosteroid-responsive, rapidly progressive, bilateral sensorineural hearing loss
(autoimmune inner ear disease [AIED]). Methotrexate has emerged as the benchmark agent
but has not been rigorously evaluated for hearing improvement in patients with AIED.
ObjectiveTo assess the efficacy of long-term methotrexate in maintaining hearing
improvements achieved with glucocorticoid (prednisone) therapy in patients with AIED …
corticosteroid-responsive, rapidly progressive, bilateral sensorineural hearing loss
(autoimmune inner ear disease [AIED]). Methotrexate has emerged as the benchmark agent
but has not been rigorously evaluated for hearing improvement in patients with AIED.
ObjectiveTo assess the efficacy of long-term methotrexate in maintaining hearing
improvements achieved with glucocorticoid (prednisone) therapy in patients with AIED …