A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration
J Waning, J Vriens, G Owsianik, L Stüwe, S Mally… - Cell calcium, 2007 - Elsevier
Cell migration relies on a tight temporal and spatial regulation of the intracellular Ca2+
concentration ([Ca2+] i).[Ca2+] i in turn depends on Ca2+ influx via channels in the plasma
membrane whose molecular nature is still largely unknown for migrating cells. A
mechanosensitive component of the Ca2+ influx pathway was suggested. We show here
that the capsaicin-sensitive transient receptor potential channel TRPV1, that plays an
important role in pain transduction, is one of the Ca2+ influx channels involved in cell …
concentration ([Ca2+] i).[Ca2+] i in turn depends on Ca2+ influx via channels in the plasma
membrane whose molecular nature is still largely unknown for migrating cells. A
mechanosensitive component of the Ca2+ influx pathway was suggested. We show here
that the capsaicin-sensitive transient receptor potential channel TRPV1, that plays an
important role in pain transduction, is one of the Ca2+ influx channels involved in cell …