Molecular basis of colorectal cancer
SD Markowitz, MM Bertagnolli - New England journal of …, 2009 - Mass Medical Soc
SD Markowitz, MM Bertagnolli
New England journal of medicine, 2009•Mass Medical SocThis review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic
mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are
the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression
from adenoma to carcinoma and probably influence individual susceptibility and response to
treatment.
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic
mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are
the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression
from adenoma to carcinoma and probably influence individual susceptibility and response to
treatment.
This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.
The New England Journal Of Medicine