TRP channels as cellular sensors

DE Clapham - Nature, 2003 - nature.com
Nature, 2003nature.com
TRP channels are the vanguard of our sensory systems, responding to temperature, touch,
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than
classical sensory transduction. They are an ancient sensory apparatus for the cell, not just
the multicellular organism, and they have been adapted to respond to all manner of stimuli,
from both within and outside the cell.
Abstract
TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.
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