[HTML][HTML] Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related …
Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte antigen-
related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and
humans. Overexpression of LAR selectively in muscle of transgenic mice causes whole
body insulin resistance. To determine whether overexpression of PTP1B also causes insulin
resistance, we generated transgenic mice overexpressing human PTP1B selectively in …
related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and
humans. Overexpression of LAR selectively in muscle of transgenic mice causes whole
body insulin resistance. To determine whether overexpression of PTP1B also causes insulin
resistance, we generated transgenic mice overexpressing human PTP1B selectively in …