[HTML][HTML] Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes
Y Zhang, Z Wang, DX Liu, M Pagano… - Journal of Biological …, 1998 - ASBMB
During the endomitotic cell cycle of megakaryocytic cell lines, the levels of cyclin B1 and the
activity of cyclin B1-dependent Cdc2 kinase, although detectable, are reduced as compared
with megakaryocytes undergoing a mitotic cell cycle. The levels of cyclin A, however, are
comparable during both cell cycles. The expression of cyclin B1 mRNA is also equivalent in
proliferating and polyploidizing cells. In the current study, we found that the rate of cyclin B1
protein degradation is enhanced in polyploidizing megakaryocytes. This finding has led us …
activity of cyclin B1-dependent Cdc2 kinase, although detectable, are reduced as compared
with megakaryocytes undergoing a mitotic cell cycle. The levels of cyclin A, however, are
comparable during both cell cycles. The expression of cyclin B1 mRNA is also equivalent in
proliferating and polyploidizing cells. In the current study, we found that the rate of cyclin B1
protein degradation is enhanced in polyploidizing megakaryocytes. This finding has led us …