Drug eluting stents: are human and animal studies comparable?
R Virmani, FD Kolodgie, A Farb, A Lafont - Heart, 2003 - heart.bmj.com
R Virmani, FD Kolodgie, A Farb, A Lafont
Heart, 2003•heart.bmj.comAnimal models of stenting probably predict human responses as the stages of healing are
remarkably similar. What is characteristically different is the temporal response to healing,
which is substantially prolonged in humans. The prevention of restenosis in recent clinical
trials of drug eluting stents may represent a near absent or incomplete phase of intimal
healing. Continued long term follow up of patients with drug eluting stents for major adverse
cardiac events and angiographic restenosis is therefore imperative.
remarkably similar. What is characteristically different is the temporal response to healing,
which is substantially prolonged in humans. The prevention of restenosis in recent clinical
trials of drug eluting stents may represent a near absent or incomplete phase of intimal
healing. Continued long term follow up of patients with drug eluting stents for major adverse
cardiac events and angiographic restenosis is therefore imperative.
Animal models of stenting probably predict human responses as the stages of healing are remarkably similar. What is characteristically different is the temporal response to healing, which is substantially prolonged in humans. The prevention of restenosis in recent clinical trials of drug eluting stents may represent a near absent or incomplete phase of intimal healing. Continued long term follow up of patients with drug eluting stents for major adverse cardiac events and angiographic restenosis is therefore imperative.
heart.bmj.com