[HTML][HTML] Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1

SC Moss, DJ Lightell, SO Marx, AR Marks… - Journal of biological …, 2010 - ASBMB
Rapamycin is a macrolide antibiotic that inhibits vascular smooth muscle cell proliferation
and migration and that is used clinically on drug-eluting stents to inhibit in-stent restenosis.
Although inhibition of cell migration is an asset in preventing restenosis, it also leads to
impaired stent endothelialization, a significant limitation of current drug-eluting stent
technology that necessitates prolonged antiplatelet therapy. We measured the ability of
rapamycin to inhibit the migration of human umbilical vein endothelial cells (HUVECs) and …