Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
BD Brown, L Naldini - Nature Reviews Genetics, 2009 - nature.com
BD Brown, L Naldini
Nature Reviews Genetics, 2009•nature.comNew technologies are emerging that utilize artificial microRNA (miRNA) target sites to exploit
or inhibit endogenous miRNA regulation. This approach has been used to improve cell-
specific targeting for gene and stem cell therapy studies and for animal transgenics, and
also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets
have also been used to sponge or decoy miRNAs as a way to study their functions. This
article considers the benefits of this approach and design considerations for future studies.
or inhibit endogenous miRNA regulation. This approach has been used to improve cell-
specific targeting for gene and stem cell therapy studies and for animal transgenics, and
also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets
have also been used to sponge or decoy miRNAs as a way to study their functions. This
article considers the benefits of this approach and design considerations for future studies.
Abstract
New technologies are emerging that utilize artificial microRNA (miRNA) target sites to exploit or inhibit endogenous miRNA regulation. This approach has been used to improve cell-specific targeting for gene and stem cell therapy studies and for animal transgenics, and also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets have also been used to sponge or decoy miRNAs as a way to study their functions. This article considers the benefits of this approach and design considerations for future studies.
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