Recovery from deafness in a patient with Muckle‐Wells syndrome treated with anakinra

T Mirault, D Launay, L Cuisset… - … : Official Journal of …, 2006 - Wiley Online Library
T Mirault, D Launay, L Cuisset, E Hachulla, M Lambert, V Queyrel, T Quemeneur…
Arthritis & Rheumatism: Official Journal of the American College …, 2006Wiley Online Library
Muckle‐Wells syndrome (MWS) is a dominantly inherited autoinflammatory disease
characterized by rashes, fever, arthralgia, sensorineural deafness, and the possible
development of systemic AA amyloidosis. We used anakinra to treat a 22‐year‐old patient
with MWS who had deafness and a high serum level of C‐reactive protein (CRP). Following
treatment with anakinra, the patient's CRP level normalized, and she recovered from
deafness. The fact that this occurrence has never been previously reported strengthens the …
Abstract
Muckle‐Wells syndrome (MWS) is a dominantly inherited autoinflammatory disease characterized by rashes, fever, arthralgia, sensorineural deafness, and the possible development of systemic AA amyloidosis. We used anakinra to treat a 22‐year‐old patient with MWS who had deafness and a high serum level of C‐reactive protein (CRP). Following treatment with anakinra, the patient's CRP level normalized, and she recovered from deafness. The fact that this occurrence has never been previously reported strengthens the role of anakinra in MWS but also raises new questions about the physiopathology of such deafness.
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