[HTML][HTML] The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53

P Stanhope-Baker, PM Kessler, W Li… - Journal of Biological …, 2004 - ASBMB
Wilms tumors are a heterogeneous class of tumors in which Wilms tumor suppressor-1
(WT1) and the p53 tumor suppressor may be variously inactivated by mutation, reduced in
expression, or even overexpressed in the wild-type state. The downstream transcriptional
targets of WT1 and p53 that are critical for mediating their roles in Wilms tumorigenesis are
not well defined. The WiT49 cell line is characteristic of anaplastic Wilms tumors that are
refractory to treatment and expresses wild-type WT1 and mutant p53. We have used the …