Local heart irradiation of ApoE−/− mice induces microvascular and endocardial damage and accelerates coronary atherosclerosis
K Gabriels, S Hoving, I Seemann, NL Visser… - Radiotherapy and …, 2012 - Elsevier
BACKGROUND AND PURPOSE: Radiotherapy of thoracic and chest-wall tumors increases
the long-term risk of radiation-induced heart disease, like a myocardial infarct. Cancer
patients commonly have additional risk factors for cardiovascular disease, such as
hypercholesterolemia. The goal of this study is to define the interaction of irradiation with
such cardiovascular risk factors in radiation-induced damage to the heart and coronary
arteries. MATERIAL AND METHODS: Hypercholesterolemic and atherosclerosis-prone …
the long-term risk of radiation-induced heart disease, like a myocardial infarct. Cancer
patients commonly have additional risk factors for cardiovascular disease, such as
hypercholesterolemia. The goal of this study is to define the interaction of irradiation with
such cardiovascular risk factors in radiation-induced damage to the heart and coronary
arteries. MATERIAL AND METHODS: Hypercholesterolemic and atherosclerosis-prone …