EGFR-TK inhibition before radiotherapy reduces tumour volume but does not improve local control: differential response of cancer stem cells and nontumourigenic …
M Krause, J Prager, X Zhou, A Yaromina… - Radiotherapy and …, 2007 - Elsevier
BACKGROUND AND PURPOSE: Waiting times before radiotherapy may reduce tumour
control probability due to proliferation of tumour cells. The aim of the experiment was to test
whether the growth inhibiting effect of epidermal growth factor receptor (EGFR)-inhibitors
after surgery or tumour transplantation results in a lower tumour mass at time of irradiation
and can thereby improve local tumour control. MATERIALS AND METHODS: The EGFR-
tyrosine kinase inhibitor BIBX1382BS was applied over 14days starting from microscopically …
control probability due to proliferation of tumour cells. The aim of the experiment was to test
whether the growth inhibiting effect of epidermal growth factor receptor (EGFR)-inhibitors
after surgery or tumour transplantation results in a lower tumour mass at time of irradiation
and can thereby improve local tumour control. MATERIALS AND METHODS: The EGFR-
tyrosine kinase inhibitor BIBX1382BS was applied over 14days starting from microscopically …