The many substrates and functions of ATM
MB Kastan, D Lim - Nature reviews Molecular cell biology, 2000 - nature.com
MB Kastan, D Lim
Nature reviews Molecular cell biology, 2000•nature.comAs its name suggests, the ATM?'ataxia-telangiectasia, mutated'? gene is responsible for the
rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their
responses to DNA damage, but also in other cellular processes. Although it is hard to
understand how a single gene product is involved in so many physiological processes, a
clear picture is starting to emerge.
rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their
responses to DNA damage, but also in other cellular processes. Although it is hard to
understand how a single gene product is involved in so many physiological processes, a
clear picture is starting to emerge.
Abstract
As its name suggests, the ATM ? 'ataxia-telangiectasia, mutated' ? gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.
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