Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration
DA Baker, H Shen, PW Kalivas - Amino acids, 2002 - Springer
DA Baker, H Shen, PW Kalivas
Amino acids, 2002•SpringerRepeated administration of cocaine lowers the basal extracellular levels of glutamate in the
nucleus accumbens as measured by microdialysis. The studies presented reveal that this
long-term neuroadaptation elicited by repeated cocaine results from a decrease in the
activity of cystine/glutamate exchange.
nucleus accumbens as measured by microdialysis. The studies presented reveal that this
long-term neuroadaptation elicited by repeated cocaine results from a decrease in the
activity of cystine/glutamate exchange.
Summary
Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.
Springer