Amyloid oligomers are believed to play important causal roles in many types of amyloid-
related degenerative diseases. Many different laboratories have reported amyloid oligomers
that differ in size, morphology, toxicity, and method of preparation or purification, raising the
question of the structural relationships among these oligomer preparations. The structural
plasticity that has been reported to occur in amyloids formed from the same protein
sequence indicates that it is quite possible that different oligomer preparations may …