[HTML][HTML] Factor XIII–an under diagnosed deficiency–are we using the right assays?
AS Lawrie, L Green, IJ Mackie, R Liesner… - Journal of Thrombosis …, 2010 - Elsevier
Background: The clot solubility test is the most widely used method for detection of factor (F)
XIII deficiency. However, it will only detect severe deficiencies; consequently mild
deficiencies and heterozygous states are probably under diagnosed. Objective: As an
alternative first‐line screening test, we assessed an automated quantitative ammonia
release assay (QARA). Patients/methods: Inter‐assay imprecision was evaluated with
commercial normal and pathological control plasmas (10 replicates on each of 5 days) …
XIII deficiency. However, it will only detect severe deficiencies; consequently mild
deficiencies and heterozygous states are probably under diagnosed. Objective: As an
alternative first‐line screening test, we assessed an automated quantitative ammonia
release assay (QARA). Patients/methods: Inter‐assay imprecision was evaluated with
commercial normal and pathological control plasmas (10 replicates on each of 5 days) …