[HTML][HTML] m-TOR inhibitors: what role in liver transplantation?

T Kawahara, S Asthana, NM Kneteman - Journal of Hepatology, 2011 - Elsevier
The development of calcineurin inhibitors (CNIs) led to marked improvements in patient and
graft survival after liver transplantation (LTx). We have been left, however, with a
dependence on immunosuppressive agents with nephrotoxicity, neurotoxicity, adverse
impacts on cardiac risk profile, and risk for malignancy. These challenges need to be met
against a dominance of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) as
indications for liver transplant. Unmet needs for immunosuppression (IS) in LTx include:(1) …