Phthalate esters as peroxisome proliferator carcinogens.
JR Warren, ND Lalwani, JK Reddy - Environmental health …, 1982 - ehp.niehs.nih.gov
The phthalate ester di (2-ethylhexyl) phthalate is both a peroxisome proliferator and a
hepatic carcinogen. Peroxisome proliferators as a class are hepatocarcinogenic in rodent
species. However, none of the peroxisome proliferators tested to date including the
phthalate esters and related alcohol and acid analogs have demonstrated mutagenic or
DNA-damaging activity in the in vitro Salmonella typhimurium/microsomal or the lymphocyte
3H-thymidine assays. A working hypothesis is proposed that peroxisome proliferation itself …
hepatic carcinogen. Peroxisome proliferators as a class are hepatocarcinogenic in rodent
species. However, none of the peroxisome proliferators tested to date including the
phthalate esters and related alcohol and acid analogs have demonstrated mutagenic or
DNA-damaging activity in the in vitro Salmonella typhimurium/microsomal or the lymphocyte
3H-thymidine assays. A working hypothesis is proposed that peroxisome proliferation itself …