[HTML][HTML] Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP
MHC Lam, BJ Michell, MT Fodero-Tavoletti… - Journal of Biological …, 2001 - ASBMB
Specific cellular stresses, including hyperosmotic stress, caused a dramatic but reversible
cytoplasmic accumulation of the otherwise nuclear 45-kDa variant of the protein-tyrosine
phosphatase TCPTP (TC45). In the cytoplasm, TC45 dephosphorylated the epidermal
growth factor receptor and down-regulated the hyperosmotic stress-induced activation of the
c-Jun N-terminal kinase. The hyperosmotic stress-induced nuclear exit of TC45 was not
inhibited by leptomycin B, indicating that TC45 nuclear exit was independent of the exportin …
cytoplasmic accumulation of the otherwise nuclear 45-kDa variant of the protein-tyrosine
phosphatase TCPTP (TC45). In the cytoplasm, TC45 dephosphorylated the epidermal
growth factor receptor and down-regulated the hyperosmotic stress-induced activation of the
c-Jun N-terminal kinase. The hyperosmotic stress-induced nuclear exit of TC45 was not
inhibited by leptomycin B, indicating that TC45 nuclear exit was independent of the exportin …