Regulation of TGF-β signalling by protein phosphatases

T Liu, XH Feng - Biochemical Journal, 2010 - portlandpress.com
T Liu, XH Feng
Biochemical Journal, 2010portlandpress.com
Tight regulation of TGF-β (transforming growth factor-β) superfamily signalling is important
for normal cellular functions and tissue homoeostasis. Since TGF-β superfamily signalling
pathways are activated by a short phosphorylation cascade, from receptor phosphorylation
to subsequent phosphorylation and activation of downstream signal transducer R-Smads
(receptor-activated Smads), reversible phosphorylation serves as a critical step to assure
proper TGF-β signalling. The present article will review the current progress on the …
Tight regulation of TGF-β (transforming growth factor-β) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-β superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-β signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-β signalling and the essential role of protein phosphatases in this process.
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