[HTML][HTML] Loss of β1-integrin enhances TGF-β1-induced collagen expression in epithelial cells via increased αvβ3-integrin and Rac1 activity
T Hayashida, JCR Jones, CK Lee… - Journal of biological …, 2010 - ASBMB
Transforming growth factor β (TGF-β) promotes tissue fibrosis via the receptor-specific Smad
pathway and non-canonical pathways. We recently reported that TGF-β1-stimulated
collagen expression by cultured kidney cells requires integrin-dependent activation of focal
adhesion kinase (FAK) and consequent ERK MAP kinase activity leading to Smad3 linker
region phosphorylation. Here, we defined a role for αvβ3-integrin in this non-canonical
pathway. A human kidney tubular cell line in which β1-integrin was knocked down (β1-k/d) …
pathway and non-canonical pathways. We recently reported that TGF-β1-stimulated
collagen expression by cultured kidney cells requires integrin-dependent activation of focal
adhesion kinase (FAK) and consequent ERK MAP kinase activity leading to Smad3 linker
region phosphorylation. Here, we defined a role for αvβ3-integrin in this non-canonical
pathway. A human kidney tubular cell line in which β1-integrin was knocked down (β1-k/d) …