[HTML][HTML] Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses
Defective mobilization of Ca 2+ by cardiomyocytes can lead to cardiac insufficiency, but the
causative mechanisms leading to congestive heart failure (HF) remain unclear. In the
present study we performed exhaustive global proteomics surveys of cardiac ventricle
isolated from a mouse model of cardiomyopathy overexpressing a phospholamban mutant,
R9C (PLN-R9C), and exhibiting impaired Ca 2+ handling and death at 24 weeks and
compared them with normal control littermates. The relative expression patterns of 6190 …
causative mechanisms leading to congestive heart failure (HF) remain unclear. In the
present study we performed exhaustive global proteomics surveys of cardiac ventricle
isolated from a mouse model of cardiomyopathy overexpressing a phospholamban mutant,
R9C (PLN-R9C), and exhibiting impaired Ca 2+ handling and death at 24 weeks and
compared them with normal control littermates. The relative expression patterns of 6190 …