[HTML][HTML] Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide …

BF Shaw, HL Lelie, A Durazo, AM Nersissian… - Journal of Biological …, 2008 - ASBMB
Determining the composition of aggregated superoxide dismutase 1 (SOD1) species
associated with amyotrophic lateral sclerosis (ALS), especially with respect to co-
aggregated proteins and post-translational modifications, could identify cellular or
biochemical factors involved in the formation of these aggregates and explain their apparent
neurotoxicity. The results of mass spectrometric and shotgun-proteomic analyses of SOD1-
containing aggregates isolated from spinal cords of symptomatic transgenic ALS mice using …