[HTML][HTML] Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes
C Huang, T Gurlo, L Haataja, S Costes, M Daval… - Journal of Biological …, 2010 - ASBMB
The islet in type 2 diabetes (T2DM) and the brain in neurodegenerative diseases share
progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed
amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessive activation of
the Ca 2+-sensitive protease calpain-2 has been implicated as a mediator of oligomer-
induced cell death and dysfunction in neurodegenerative diseases. To establish if human
IAPP toxicity is mediated by a comparable mechanism, we overexpressed human IAPP in rat …
progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed
amyloidogenic proteins (islet amyloid polypeptide (IAPP) in T2DM). Excessive activation of
the Ca 2+-sensitive protease calpain-2 has been implicated as a mediator of oligomer-
induced cell death and dysfunction in neurodegenerative diseases. To establish if human
IAPP toxicity is mediated by a comparable mechanism, we overexpressed human IAPP in rat …
