[HTML][HTML] Proteomic profiling of adipose tissue from Zmpste24−/− mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function …
Lipodystrophy is a major disease involving severe alterations of adipose tissue distribution
and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its
processing enzyme, the metalloproteinase Zmpste24, cause diverse human progeroid
syndromes that are commonly characterized by a selective loss of adipose tissue. Similarly
to humans, mice deficient in Zmpste24 accumulate prelamin A and display phenotypic
features of accelerated aging, including lipodystrophy. Herein, we report the proteome and …
and metabolism. Mutations in genes encoding the nuclear envelope protein lamin A or its
processing enzyme, the metalloproteinase Zmpste24, cause diverse human progeroid
syndromes that are commonly characterized by a selective loss of adipose tissue. Similarly
to humans, mice deficient in Zmpste24 accumulate prelamin A and display phenotypic
features of accelerated aging, including lipodystrophy. Herein, we report the proteome and …