Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial
A Osinusi, EG Meissner, YJ Lee, D Bon, L Heytens… - Jama, 2013 - jamanetwork.com
Importance The efficacy of directly acting antiviral agents in interferon-free regimens for the
treatment of chronic hepatitis C infections needs to be evaluated in different populations.
Objective To determine the efficacy and safety of sofosbuvir with weight-based or low-dose
ribavirin among a population with unfavorable treatment characteristics. Design, Setting, and
Patients Single-center, randomized, 2-part, open-label phase 2 study involving 60 treatment-
naive patients with hepatitis C virus (HCV) genotype 1 enrolled at the National Institutes of …
treatment of chronic hepatitis C infections needs to be evaluated in different populations.
Objective To determine the efficacy and safety of sofosbuvir with weight-based or low-dose
ribavirin among a population with unfavorable treatment characteristics. Design, Setting, and
Patients Single-center, randomized, 2-part, open-label phase 2 study involving 60 treatment-
naive patients with hepatitis C virus (HCV) genotype 1 enrolled at the National Institutes of …