[HTML][HTML] Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis
LM Giles, L Li, LS Chin - Journal of biological chemistry, 2009 - ASBMB
Early onset generalized dystonia (DYT1) is an autosomal dominant neurological disorder
caused by deletion of a single glutamate residue (torsinA ΔE) in the C-terminal region of the
AAA+(ATPases associated with a variety of cellular activities) protein torsinA. The
pathogenic mechanism by which torsinA ΔE mutation leads to dystonia remains unknown.
Here we report the identification and characterization of a 628-amino acid novel protein,
printor, that interacts with torsinA. Printor co-distributes with torsinA in multiple brain regions …
caused by deletion of a single glutamate residue (torsinA ΔE) in the C-terminal region of the
AAA+(ATPases associated with a variety of cellular activities) protein torsinA. The
pathogenic mechanism by which torsinA ΔE mutation leads to dystonia remains unknown.
Here we report the identification and characterization of a 628-amino acid novel protein,
printor, that interacts with torsinA. Printor co-distributes with torsinA in multiple brain regions …