Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance
DR McIlroy, G Wagener, HT Lee - Clinical Journal of the American …, 2010 - journals.lww.com
Abstract Background and objectives: Neutrophil Gelatinase-Associated Lipocalin (NGAL) is
rapidly released by renal tubules after injury, potentially allowing early identification of acute
kidney injury (AKI) after cardiac surgery. However, the diagnostic performance of NGAL has
varied widely in clinical studies, and it remains unknown what factors modify the relationship
between NGAL and AKI. We hypothesized the relationship between urinary NGAL and AKI
would vary with baseline renal function, allowing a stratified analysis to improve diagnostic …
rapidly released by renal tubules after injury, potentially allowing early identification of acute
kidney injury (AKI) after cardiac surgery. However, the diagnostic performance of NGAL has
varied widely in clinical studies, and it remains unknown what factors modify the relationship
between NGAL and AKI. We hypothesized the relationship between urinary NGAL and AKI
would vary with baseline renal function, allowing a stratified analysis to improve diagnostic …