[HTML][HTML] p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells
The fully executed epidermal growth factor receptor (EGFR)/Ras/MEK/ERK pathway serves
a pro-survival role in renal epithelia under moderate oxidative stress. We and others have
demonstrated that during severe oxidative stress, however, the activated EGFR is
disconnected from ERK activation in cultured renal proximal tubule cells and also in renal
proximal tubules after ischemia/reperfusion injury, resulting in necrotic death. Studies have
shown that the tyrosine-phosphorylated p46/52 isoforms of the ShcA family of adaptor …
a pro-survival role in renal epithelia under moderate oxidative stress. We and others have
demonstrated that during severe oxidative stress, however, the activated EGFR is
disconnected from ERK activation in cultured renal proximal tubule cells and also in renal
proximal tubules after ischemia/reperfusion injury, resulting in necrotic death. Studies have
shown that the tyrosine-phosphorylated p46/52 isoforms of the ShcA family of adaptor …