Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice
A Stengel, L Wang, M Goebel-Stengel, Y Taché - Neuroreport, 2011 - journals.lww.com
Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei
involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We
examined how kisspeptin-10 influences feeding after intracerebroventricular injection in
mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently
inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during
the 2–3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake …
involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We
examined how kisspeptin-10 influences feeding after intracerebroventricular injection in
mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently
inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during
the 2–3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake …