Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

YJ Lin, L Seroude, S Benzer - Science, 1998 - science.org
YJ Lin, L Seroude, S Benzer
Science, 1998science.org
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations
that extend life-span in Drosophila melanogaster was performed. The mutant line
methuselah (mth) displayed approximately 35 percent increase in average life-span and
enhanced resistance to various forms of stress, including starvation, high temperature, and
dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology
to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain …
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah(mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
AAAS