[HTML][HTML] Activation of TRPV1 by the satiety factor oleoylethanolamide
GP Ahern - Journal of Biological Chemistry, 2003 - ASBMB
The fatty acid oleoylethanolamide (OEA) is a satiety factor that excites peripheral vagal
sensory nerves, but the mechanism by which this occurs and the molecular targets of OEA
are unclear. In this study the ability of OEA to modulate the capsaicin receptor (TRPV1) was
explored. OEA alone did not activate TRPV1 expressed in Xenopus oocytes under control
conditions, but produced a differential modulation of agonist-evoked responses. OEA
enhanced proton-gated TRPV1 currents, inhibited anandamide-evoked currents and had no …
sensory nerves, but the mechanism by which this occurs and the molecular targets of OEA
are unclear. In this study the ability of OEA to modulate the capsaicin receptor (TRPV1) was
explored. OEA alone did not activate TRPV1 expressed in Xenopus oocytes under control
conditions, but produced a differential modulation of agonist-evoked responses. OEA
enhanced proton-gated TRPV1 currents, inhibited anandamide-evoked currents and had no …