[HTML][HTML] Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice [S]
We evaluated the biological basis of reduced fat gain by oleoylethanolamide (OEA) in high-
fat-fed mice and sought to determine how degradation of OEA affected its efficiency by
comparing its effects to those of KDS-5104, a nonhydrolyzable lipid OEA analog. Mice were
given OEA or KDS-5104 by the oral route (100 mg/kg body weight). Sixty-eight variables per
mouse, describing six biological processes (lipid transport, lipogenesis, energy intake,
energy expenditure, endocannabinoid signaling, and glucose metabolism), spanning gene …
fat-fed mice and sought to determine how degradation of OEA affected its efficiency by
comparing its effects to those of KDS-5104, a nonhydrolyzable lipid OEA analog. Mice were
given OEA or KDS-5104 by the oral route (100 mg/kg body weight). Sixty-eight variables per
mouse, describing six biological processes (lipid transport, lipogenesis, energy intake,
energy expenditure, endocannabinoid signaling, and glucose metabolism), spanning gene …