Deregulated expression of Kruppel-like factors in acute myeloid leukemia
M Humbert, V Halter, D Shan, J Laedrach… - Leukemia research, 2011 - Elsevier
The known participation of Kruppel-like transcription factors (KLF) in cellular differentiation
prompted us to investigate their expression in acute myeloid leukemia (AML) blast cells that
are typically blocked in their differentiation. We determined the expression patterns of KLFs
with a putative role in myeloid differentiation in a large cohort of primary AML patient
samples, CD34+ progenitor cells and granulocytes from healthy donors. We found that
KLF2, KLF3, KLF5 and KLF6 are significantly lower expressed in AML blast and CD34+ …
prompted us to investigate their expression in acute myeloid leukemia (AML) blast cells that
are typically blocked in their differentiation. We determined the expression patterns of KLFs
with a putative role in myeloid differentiation in a large cohort of primary AML patient
samples, CD34+ progenitor cells and granulocytes from healthy donors. We found that
KLF2, KLF3, KLF5 and KLF6 are significantly lower expressed in AML blast and CD34+ …