Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter
NJG Webster, Y Kong, P Sharma, M Haas… - … and molecular medicine, 1997 - Elsevier
The Wilms tumor gene WT1 has been implicated in the early development of the kidney.
Mutations in WT1 are found in a small fraction of Wilms tumor, a pediatric nephroblastoma,
and Denys–Drash syndrome, characterized by genitourinary abnormalities. The WT1 gene
product functions as a transcriptional repressor of growth factor-related genes. The kidney is
one of the major sites of insulin actionin vivoand expresses high levels of insulin receptors
(IR). IR expression has been detected during early embryogenesis, suggesting that it may …
Mutations in WT1 are found in a small fraction of Wilms tumor, a pediatric nephroblastoma,
and Denys–Drash syndrome, characterized by genitourinary abnormalities. The WT1 gene
product functions as a transcriptional repressor of growth factor-related genes. The kidney is
one of the major sites of insulin actionin vivoand expresses high levels of insulin receptors
(IR). IR expression has been detected during early embryogenesis, suggesting that it may …