Transcription factors in liver development, differentiation, and regeneration
RH Costa, VV Kalinichenko, AXL Holterman… - Hepatology, 2003 - journals.lww.com
Transcriptional Activation. The liver performs essential functions in the body by uniquely
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and
enzymes involved in detoxification, gluconeogenesis, glycogen synthesis, and glucose, fat,
and cholesterol metabolism. 1 Functional analysis of numerous hepatocyte-specific DNA
regulatory regions (promoter and enhancer regions) reveals that they are composed of
multiple cis-acting DNA sequences that bind different families of liver-enriched transcription …
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and
enzymes involved in detoxification, gluconeogenesis, glycogen synthesis, and glucose, fat,
and cholesterol metabolism. 1 Functional analysis of numerous hepatocyte-specific DNA
regulatory regions (promoter and enhancer regions) reveals that they are composed of
multiple cis-acting DNA sequences that bind different families of liver-enriched transcription …