Context Glioblastomas—uniformly fatal brain tumors—often have both monosomy of
chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on
chromosome 7, an association for which the mechanism is poorly understood. Objectives To
assess whether coselection of EGFR gains on 7p12 and monosomy 10 in glioblastomas
promotes tumorigenic epidermal growth factor (EGF) signaling through loss of the annexin
A7 (ANXA7) gene on 10q21. 1-q21. 2 and whether ANXA7 acts as a tumor suppressor gene …