The main pathology underlying motor symptoms in Parkinson's disease (PD) is a rather
selective degeneration of nigrostriatal dopamine (DA) neurons. Intrastriatal transplantation
of immature DA neurons, which replace those neurons that have died, leads to functional
restoration in animal models of PD. Here we describe how far the clinical translation of the
DA neuron replacement strategy has advanced. We briefly summarize the lessons learned
from the early clinical trials with grafts of human fetal mesencephalic tissue, and discuss …