Protective role of IL-33/ST2 axis in Con A-induced hepatitis
V Volarevic, M Mitrovic, M Milovanovic, I Zelen… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: We used Concanavalin A-induced liver injury to study the role of
Interleukin 33 and its receptor ST2 in the induction of inflammatory pathology and
hepatocellular damage. METHODS: We tested susceptibility to Concanavalin A induced
hepatitis in ST2 deficient and wild type BALB/c mice and analyzed the effects of single
injection of Interleukin 33 as evaluated by liver enzyme test, quantitative histology,
mononuclear cell infiltration, cytokine production, intracellular staining of immune cells, and …
Interleukin 33 and its receptor ST2 in the induction of inflammatory pathology and
hepatocellular damage. METHODS: We tested susceptibility to Concanavalin A induced
hepatitis in ST2 deficient and wild type BALB/c mice and analyzed the effects of single
injection of Interleukin 33 as evaluated by liver enzyme test, quantitative histology,
mononuclear cell infiltration, cytokine production, intracellular staining of immune cells, and …