[HTML][HTML] Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling
Monoamine oxidase (MAO) is a key enzyme responsible for the degradation of serotonin,
norepinephrine, dopamine, and phenylethylamine. It is an outer membrane mitochondrial
enzyme existing in two isoforms, A and B. We have recently generated 14 site-directed
mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397,
Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296,
Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity. Based on the …
norepinephrine, dopamine, and phenylethylamine. It is an outer membrane mitochondrial
enzyme existing in two isoforms, A and B. We have recently generated 14 site-directed
mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397,
Tyr-407, and Tyr-444, in MAO A and their corresponding amino acids in MAO B, Lys-296,
Trp-388, Tyr-398, and Tyr-435, play important roles in MAO catalytic activity. Based on the …