[HTML][HTML] Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition …
FR Murphy, R Issa, X Zhou, S Ratnarajah… - Journal of Biological …, 2002 - ASBMB
The activated hepatic stellate cell (HSC) is central to liver fibrosis as the major source of
collagens I and III and the tissue inhibitors of metalloproteinase-1 (TIMP-1). During
spontaneous recovery from liver fibrosis, there is a decrease of TIMP expression, an
increase in collagenase activity, and increased apoptosis of HSC, highlighting a potential
role for TIMP-1 in HSC survival. In this report, we use tissue culture and in vivomodels to
demonstrate that TIMP-1 directly inhibits HSC apoptosis. TIMP-1 demonstrated a consistent …
collagens I and III and the tissue inhibitors of metalloproteinase-1 (TIMP-1). During
spontaneous recovery from liver fibrosis, there is a decrease of TIMP expression, an
increase in collagenase activity, and increased apoptosis of HSC, highlighting a potential
role for TIMP-1 in HSC survival. In this report, we use tissue culture and in vivomodels to
demonstrate that TIMP-1 directly inhibits HSC apoptosis. TIMP-1 demonstrated a consistent …