Regression of existing glomerulosclerosis by inhibition of aldosterone
JC Aldigier, T Kanjanbuch, LJ Ma… - Journal of the …, 2005 - journals.lww.com
In this study, the effects of inhibition of aldosterone on regression of existing hypertension-
related glomerulosclerosis were investigated. Adult male Sprague Dawley rats (220 to 250
g) underwent 5/6 nephrectomy (Nx). Severity of glomerulosclerosis was assessed by renal
biopsy 8 wk later, and rats were divided into four groups with equal biopsy sclerosis and
then randomized by group to 4-wk treatments as follows: Control with no further treatment
(CONT; n= 6); spironolactone (SP) alone (200 mg/kg per d, by gavage, n= 6); or SP …
related glomerulosclerosis were investigated. Adult male Sprague Dawley rats (220 to 250
g) underwent 5/6 nephrectomy (Nx). Severity of glomerulosclerosis was assessed by renal
biopsy 8 wk later, and rats were divided into four groups with equal biopsy sclerosis and
then randomized by group to 4-wk treatments as follows: Control with no further treatment
(CONT; n= 6); spironolactone (SP) alone (200 mg/kg per d, by gavage, n= 6); or SP …
