Kidney pericytes: a novel therapeutic target in interstitial fibrosis

SW Smith, C Schrimpf, DJ Parekh, M Venkatachalam… - 2012 - digitum.um.es
SW Smith, C Schrimpf, DJ Parekh, M Venkatachalam, JS Duffield
2012digitum.um.es
Chronic Kidney Disease affects approximately 8% of the population and contributes
considerably to premature morbidity and mortality. Recently reported studies have
highlighted an important role for resident microvascular pericytes in the pathogenesis of
kidney fibrosis. Pericytes are emerging as the predominant source of the activated, matrix
depositing, stromal cell population seen in progressive fibrosis. Further, pericyte activation
leads to their detachment from the vasculature, triggers unstable microvasculature and leads …
Chronic Kidney Disease affects approximately 8% of the population and contributes considerably to premature morbidity and mortality. Recently reported studies have highlighted an important role for resident microvascular pericytes in the pathogenesis of kidney fibrosis. Pericytes are emerging as the predominant source of the activated, matrix depositing, stromal cell population seen in progressive fibrosis. Further, pericyte activation leads to their detachment from the vasculature, triggers unstable microvasculature and leads to rarefaction. Strategies to modulate pericyte function in these processes are therefore therapeutically attractive. In this review we will first describe our current understanding of the structure and function of the pericyte and the role these cells play in angiogenesis and the pathogenesis of renal fibrosis. Novel therapeutic approaches targeting pericytes in murine models of renal disease will then be considered.
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