Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

G Marchetti, GM Bellistrė, E Borghi, C Tincati… - Aids, 2008 - journals.lww.com
G Marchetti, GM Bellistrė, E Borghi, C Tincati, S Ferramosca, M La Francesca, G Morace…
Aids, 2008journals.lww.com
Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active
antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease
progression. We show heightened circulating lipopolysaccharide associated with plasma
enterobacterial DNA and highly activated Ki67+ CD4+ CD8+ in 24 immunologic-
nonresponders (CD4+ T-cell≤ 200; HIV-RNA≤ 50) compared with 11 full responders
(CD4+ T-cell≥ 400; HIV-RNA≤ 50). These data provide novel insight into INRs …
Abstract
Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+ CD4+ CD8+ in 24 immunologic-nonresponders (CD4+ T-cell≤ 200; HIV-RNA≤ 50) compared with 11 full responders (CD4+ T-cell≥ 400; HIV-RNA≤ 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.
Lippincott Williams & Wilkins