OBJECTIVE: There is a growing interest in the potential anti-inflammatory properties of
sevelamer hydrochloride, a commonly used phosphate binder for patients with chronic
kidney failure. This study explores the hypothesis that sevelamer hydrochloride binds
bacterial endotoxin in the intestinal tract, leading to lower circulating endotoxin levels, and
offering a novel anti-inflammatory mechanism. METHODS: We performed a cross-sectional
study in medically stable patients with chronic kidney failure undergoing maintenance …