Hemolysis, long discounted as a critical measure of sickle cell disease severity when
compared with sickle vaso-occlusion, may be the proximate cause of some disease
complications. New mechanistic information about hemolysis and its effects on nitric oxide
(NO) biology and further examination of the subphenotypes of disease requires a
reappraisal and deconstruction of the clinical features of sickle cell disease. The biology
underlying clinical phenotypes linked to hemolysis may increase our understanding of the …