p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling
P Pamonsinlapatham, R Hadj-Slimane, Y Lepelletier… - Biochimie, 2009 - Elsevier
p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP
bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-
terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-
dependent phospholipid-binding domain) domains. These protein domains allow various
functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of
their distinct partners. The p120-RasGAP domain participates in protein–protein interactions …
bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-
terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-
dependent phospholipid-binding domain) domains. These protein domains allow various
functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of
their distinct partners. The p120-RasGAP domain participates in protein–protein interactions …